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Tokyo Women's Medical University

TEL. 03-3353-8111

〒162-8666 8-1, Kawada-cho, Shinjuku-ku, Tokyo

School of Medicine

School of Medicine

Physiology (Neurophysiology)

Overview

Our department is responsible for medical education in physiology, covering the field of neuroscience with a focus on neurophysiology.
Neuroscience continues to develop in close relationship with a wide range of academic fields, from basic to clinical and engineering. In recent years, new technologies such as cell imaging using fluorescent proteins, iPS cells, viral genetics, and optogenetics have been developed, neural circuits work and higher-order functions that decipher the human mind are getting revealed, which until now have been too complex to understand.
Our research focuses on the function of neural networks, which are the basis of brain functions. How do neural circuits change during postnatal development? How are these circuits affected by various external changes such as nerve damage and sensory deprivation? By focusing these questions, we aim to clarify the principle of plasticity of neural circuits and to elucidate some aspects of brain function. We use the methods such as electrophysiology, molecular biology, imaging, and optogenetics to observe the functions of neural circuits in vitro and in vivo. We are also collaborating with clinical departments for the analysis of neural functions. These series of studies may lead to the elucidation of intractable pain such as phantom limb pain and developmental disorders such as autism.

Education Details

In the first grade, we conduct lectures on "Cells and Signal Transduction," "Genes and Genetics," and "Biological Systems and Regulatory Mechanisms" as well as practical and tutorial training on "Biological Systems and Regulatory Mechanisms. In the second year, we conduct lectures on "Fundamentals of Therapy," "Cardiovascular System 1" and "Respiratory System 1," as well as "Physiological Practice.
In the third year, we conduct lectures on "Cerebral Nervous System 1," "Mental System," "Hearing, Ear, Nose & Throat System," and "Eye and Vision System," and "Neurophysiological Practice for Cerebral Nervous System 1.”
In the fourth grade, we conduct lectures on "Blood and Lymphatic System. In the School of Nursing, we conduct lectures on "Reception and Processing of Information" and "Somatosensory and Sensory Organ Functions" in Physiology.

Research Details

Research focusing on the operation of neural circuits, the basis for brain function, is being performed. How do neural circuits change during the post-birth developmental period? How are they affected by various changes in the external world, such as neuronal injury and sensory deprivation? The aim of the research is to clarify the neural circuit plasticity principle by focusing on those questions, and thus to elucidate an aspect of brain function. The methods used, both in vitro and in vivo, to assess the operation of neural circuits are based on electrophysiology, molecular biology, imaging, optogenetics, etc. In addition, good progress is being made in analysis of neural function on the basis of research in collaboration with clinical classrooms.

Faculty

Mariko Miyata
Mitsuharu Midorikawa

Graduate School

In our graduate school, we conduct following lectures and practical trainings. "Integrated Functions of the Nervous System (Sensory and Motor)," "Sensory Reception and Signal Transmission Mechanisms" as a general review of neurophysiology, "Correlation of Neuronal Morphology and Function" as an Advanced Course of Nervous System Functional Morphology, "Remodeling Mechanisms of Upper Central Neuronal Circuits in Neural Injury" as Neuronal Circuit Information Theory, "Development of Neuronal Circuits and Maintenance Mechanisms after Maturation" as a section on Neural Circuits and Neural Plasticity”, "Nociceptive Sensations and Pain" "Somatic and Special Senses”, "Modalities", "Critical Periods of Sensory Pathway Development and Their Disorders," and "Emotion and Memory in Pain" as sensory physiology items.
The research details of our laboratory are listed above. If you are interested in these topics, please contact Dr. Miyata. We are actively recruiting graduate students.

Related links

Physiology(Neurophysiology) HP
Research Achievements Database


バナースペース

Tokyo Women's Medical University

〒162-8666
8-1, Kawada-cho, Shinjuku-ku, Tokyo

TEL +81-3-3353-8111