〒162-8666 8-1, Kawada-cho, Shinjuku-ku, Tokyo
We focus on cancer- and inflammation-related genes in tumor cell proliferation and metastasis and have been investigating roles of those genes in a metastatic process composed by tumor growth at primary site, extravasation, intravasation, and regrowth at metastasized sites. We also examine effects of primary tumors on tumor microenvironment and pre-metastatic organs. We use various experimental materials such as vascular endothelial, bone marrow, pulmonary epithelial, liver, and immune cells with various experimental techniques, and each researcher vigorously promotes own research project at own discretion.
(1) Signal transduction in cancer 1) Molecular functions of oncogene and
tumor suppressor 2) Cellular pharmacology of tumor-bearing or leukemia
(2) Molecular biology of vascular endothelial cells 1) Growth factor signaling 2) Vascular development
(3) Molecular biology of Reactive oxygen species (ROS)-related signal 1) Regulation of gene expression by ROS and/or free radicals 2) Molecular mechanisms of ROS production
(4) Molecular biology of chaperons 1) Molecular functions of Heat shock proteins（HSP-54, -70, -90）in stress signal 2) Dysfunction of HSPs in pathophysiological settings 3) Molecular interactions regulated by chaperons and drugs
(5) Molecular biology of steroid-responsive factors 1) Regulatory mechanism of the glucocorticoid receptor 2) Regulatory mechanism of steroid-related signal by glucocorticoid receptor-binding proteins
Prof. Yoshiro Maru
Degree: M.D., Ph.D.
Research interest: Inflammation and Metastasis, CML, angiogenesis
8-1, Kawada-cho, Shinjuku-ku, Tokyo