共同研究をしている 福谷悌和 先生（神戸総合医療専門学校）の論文です。
“Tumor volume and calcifications as indicators for preoperative differentiation of grade II/III diffuse gliomas”
FUKUYA Yasukazu†, TAMURA Manabu*, NITTA Masayuki, SAITO Taiichi, TSUZUKI Shunsuke, KORIYAMA Shunichi, KUWANO Atsushi, KAWAMATA Takakazu, MURAGAKI Yoshihiro
Journal of Neuro-Oncology, Online ahead of print (2023)
Purpose: To retrospectively evaluate preoperative clinical factors for their ability to preoperatively differentiate malignancy grades in patients with incipient supratentorial grade II/III diffuse gliomas.
Methods: This retrospective study included 206 adult patients with incipient supratentorial grade II/III diffuse gliomas according to the 2016 World Health Organization classification of tumors of the central nervous system. The cohort included 136 men and 70 women, with a median age of 41 years. Preoperative factors included age, sex, presence of calcifications on computed tomography scans, and preoperative tumor volume measured using preoperative magnetic resonance imaging.
Results: In patients with oligodendrogliomas (IDH-mutant and 1p/19q-codeleted), calcifications were significantly more frequent (p = 0.0034) and tumor volume was significantly larger (p < 0.001) in patients with grade III tumors than in those with grade II tumors. Moreover, in patients with IDH-mutant astrocytomas, preoperative tumor volume was significantly larger (p = 0.0042) in patients with grade III tumors than in those with grade II tumors. In contrast, none of the evaluated preoperative clinical factors were significantly different between the patients with grade II and III IDH-wildtype astrocytomas.
Conclusion: In adult patients with suspicison incipient supratentorial grade II/III diffuse gliomas, presence of calcifications and larger preoperative tumor volume might be used as preoperative indices to differentiate between malignancy grades II and III in oligodendrogliomas (IDH-mutant and 1p/19q-codeleted) and larger preoperative tumor volume might have similar utility in IDH-mutant astrocytomas.
Keywords: Diffuse glioma; Malignancy grade; Preoperative index; Preoperative tumor volume.