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肺再生医療のためのフィーダーフリー培養による肺胞上皮細胞シート作製に関するに関する論文がRegenerave Therapy誌に掲載されました

大学院生 光星 翔太 先生(呼吸器外科)の論文です。

“A novel alveolar epithelial cell sheet fabricated under feeder-free conditions for potential use in pulmonary regenerative therapy”

MITSUBOSHI Shota†, HOMMA Jun, SEKINE Hidekazu*, TAKAGI Ryo,  SHIMIZU Tatsuya, KANZAKI Masato

Regenerave Therapy, 19, 113-121

doi:10.1016/j.reth.2022.01.005

Abstract

Introduction
Lung transplantation is the only effective treatment option for many patients with irreversible pulmonary injury, and the demand for lung transplantation is increasing worldwide and expected to continue to outstrip the number of available donors. Regenerative therapy with alveolar epithelial cells (AECs) holds promise as an alternative option to organ transplantation. AECs are usually co-cultured with mouse-derived 3T3 feeder cells, but the use of xenogeneic tissues for regenerative therapy raises safety concerns. Fabrication of AEC sheets under feeder-free conditions would avoid these safety issues. We describe a novel feeder-free method of fabricating AEC sheets that may be suitable for pulmonary regenerative therapy.

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