Tomita T, Sakurai Y, Ishibashi S, Maru Y.

Imbalance of Clara cell-mediated homeostatic inflammation is involved in lung metastasis.
Oncogene 30, 3429-3439, 2011

Hiratsuka S, Goel S, Kamoun WS, Maru Y, Fukumura D, Duda DG, Jain RK.
Endothelial focal adhesion kinase mediates cancer cell homing to discrete regions of the lungs via E-selectin up-regulation.
Proc Natl Acad Sci U S A. 108, 3725-3730, 2011

Kido T, Tomita T, Okamoto M, Cai Y, Matsumoto Y, Vinson C, Maru Y, Kimura S.

FOXA1 plays a role in regulating secretoglobin 1a1 expression in the absence of CCAAT/enhancer binding protein activities in lung in vivo.

Am J Physiol Lung Cell Mol Physiol. 2011 Mar;300(3):L441-52.

Maru Y.

Endogenous ligand-induced activation of TLR4 in Pre-metastatic phase is both downstream and upstream of TNF signaling.
Adv Exp Med Biol. 691, 261-268, 2011

2010年

Tsukahara F, Maru Y.
Bag1 directly routes immature BCR-ABL for proteasomal degradation
Blood, 116, 3582-3592, 2010
Comment fromBlood: Wrapping BCR-ABL: its in the bag, Junia V. Melo and Duncan R. Hewett

Maru Y.
Activation of TLR4 in pre-metastatic phase: crosstalk with TNF.
Proc. 12th international TNF conference (April, 2009,　Madrid), 2010, Springer.

Maru, Y.
Pre-metastatic milieu explained by TLR4 agonist-mediated homeostatic inflammation.
Cell and Mol. Immun., 7, 94-99, 2010

XPB induces C1D expression to counteract UV-induced apoptosis.
Mol Cancer Res. 8, 885-895, 2010

2009年

Maru Y.
A  Concept of Homeostatic Inflammation Provided by Endogenous TLR4 Agonists that Function Before and After Danger Signal for Metastasis.
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry. 8, 337-347, 2009

Maru Y.
Logical structures extracted from metastasis experiments.
Cancer Sci. 100, 2006-2013, 2009

Yamazaki T, Masuda J, Omori T, Usui R, Akiyama H, Maru Y.
EphA1 interacts with integrin-linked kinase and regulates cell morphology and motility.
J Cell Sci., 122, 243-255, 2009.

Maru, Y.
The tumor suppressor LZTS2 functions through the cellular samurai Katanin
Cent. Eur. J. Biol., 4, 1-10, 2009.

2008年

Hiratsuka S, Watanabe A, Sakurai Y, Akashi-Takamura S, Ishibashi S, Miyake K, Shibuya M, Akira S, Aburatani H, Maru Y.
The S100A8-serum amyloid A3-TLR4 paracrine cascade establishes a pre-metastatic phase.
Nat Cell Biol., 10, 1349-1355, 2008

Sudo H, Maru Y. 
LAPSER1/LZTS2: a pluripotent tumor suppressor linked to the inhibition of katanin-mediated microtubule severing. 
Hum Mol Genet. 2008

Watanabe K, Takizawa N, Noda S, Tsukahara F, Maru Y, Kobayashi N 
Hsc70 regulates the nuclear export but not the import of influenza viral RNP: A possible target for the development of anti-influenza virus drugs. 
Drug Discov Ther., 2, 77-84, 2008 

Masuda J, Usui R, Maru Y. 
Fibronectin type I Repeat Is a Nonactivating Ligand for EphA1 and Inhibits ATF3-dependent Angiogenesis. 
J Biol Chem., 283, 13148-13155, 2008

2007年

Usui R, Shibuya M, Ishibashi S, Maru Y. 
Ligand-independent activation of vascular endothelial growth factor receptor 1 by low-density lipoprotein.
EMBO Rep., 8, 1155-1161, 2007 

Sudo H, Maru Y. 
LAPSER1 is a putative cytokinetic tumor suppressor that shows the same centrosome and midbody subcellular localization pattern as p80 katanin.
FASEB J. 2, 2086-2100, 2007 

2006年

Okamoto, A., Iwamoto, Y., and Maru, Y 
Oxidative stress-responsive transcription factor ATF3 potentially mediates diabetic angiopathy. 
Mol. Cell. Biol., 26, 1087-1097, 2006

Hiratsuka, S., Watanabe, A., Aburatani, H., and Maru, Y. 
Tumor-mediated upregulation of chemoattractants and recruitment of myeloid cells pre- determines lung metastasis.
Nat. Cell Biol., 8, 1369-1375, 2006

Ken Watanabe, Takayuki Fuse, Issay Asano, Fujiko Tsukahara, Yoshiro Maru, Kyosuke Nagata, Kaio Kitazato, and Nobuyuki Kobayashi 
Identification of Hsc70 as an influenza virus matrix protein (M1) binding factor involved in the virus life cycle
FEBS. Letters, 580, 5785-5790, 2006

2005年

Hiratsuka, S., Kataoka, Y., Nakao, K., Nakamura, K., Morikawa, S., Tanaka, S., Katsuki, M., Maru, Y. and Shibuya, M. 
VEGF-A is involved in guidance of VEGF-receptor-positive cells to anterior portion in early embryogenesis. 
Mol. Cell. Biol., 25, 355-363, 2005 

Hiratsuka, S., Nakao, K., Nakamura, K., Katsuki, M., Maru, Y. and Shibuya, M. 
Membrane-fixation of VEGFR1 ligand-binding domain is important for vasculogenesis/angiogenesis in mice. 
Mol. Cell. Biol., 25, 346-354, 2005.

Maru, Y., Nishino, T, and Kakinuma, K
Expression of Nox genes in rat organs, mouse oocytes and sea urchin eggs.
DNA Seq., 16, 83-88, 2005 

Zhang, Q. Tsukahara, F, and Maru, Y
N-acetyl-cysteine enhances growth in BCR-ABL-transformed cells. 
Cancer Sci., 96, 240-244, 2005.

Sakurai Y, Ohgimoto K, Kataoka Y, Yoshida N, and Shibuya M.
Essential role of Flk-1 (VEGF receptor 2) tyrosine residue 1173 in vasculogenesis in mice.
Proc Natl Acad Sci U S A. 2005 Jan 25;102(4):1076-81.

2004年

Tago, K., Tsukahara, F., Naruse, M., Yoshioka, T., and Takano, K.
Regulation of nuclear retention of glucocorticoid receptor bynuclear Hsp90.
Mol. Cell Endocrinol. 213 (2), 131-138, 2004

Mori, M., Tsukahara, F., Yoshioka, T., Irie, K. and Ohta, H.
Suppression by 12b-estradiol of monosyte adhesion to vascular endothelial cells is mediated by estrogen receptors.
Life Sci. 75, 599-609, 2004

Tago, K., Tsukahara, F., Naruse, M., Yoshioka, T., and Takano, K.
Hsp90 inhibitors attenuate effect of dexamethasone on activated NF-kB and AP-1.
Life Sci. 74 (16), 1981-1992, 2004

Uchida, Y.,Ohba, K.,Yoshioka, T., Irie,K., Muraki,T and Maru, Y.
Cellular carbonyl stress enhances the expression of plasminogen activator inhibitor-1 in rat white adipocytes via reactive oxygen species-dependent pathway.
J. Biol. Chem., 279: 4075-4083, 2004

Tsukahara F., Maru Y.
Identification of novel nuclear export and nuclear localization-related signals in human heat shock cognate protein 70.
J. Biol. Chem., 279(10): 8867-8872, 2004.

Kobayashi, S., Sawano, A., Nojima, Y., Shibuya, M. and Maru, Y. 
The c-Cbl/CD2AP complex regulates VEGF-induced endocytosis and degradation of Flt-1 (VEGFR-1). 
FASEB J., 18, 929-931, 2004. 

Kobayashi, S., Ito, E., Honma, R., Nojima, Y., Shibuya, M., Watanabe, S. and Maru, Y.
Dynamic regulation of gene expression by the Flt-1 kinase and Matrigel in endothelial tubulogenesis.
Genomics., 84, 185-192, 2004 

Kobayashi, S., Nojima, Y., Shibuya, M., and Maru, Y. 
Nox1 regulates formation of capillary-like networks and vascular endothelial growth factor-resistant apoptosis in sinusoidal endothelial cells. 
Exp. Cell Res., 300, 455-462, 2004 

2002年

Hiroki Miyashita, Tohru Yamazaki, Tetsuya Akada, Osamu Niizeki, Minetaro Ogawa, Shin-ichi Nishikawa, and Yasufumi Sato
A mouse orthologue of puromycin-insensitive leucyl-specific aminopeptidase is expressed in endothelial cells and plays an important role in angiogenesis.
Blood, 99: 3241-3249, 2002 

Tetsuya Akada, Tohru Yamazaki, Hiroki Miyashita, Osamu Niizeki, Mayumi Abe, Akira Sato, Susumu Satomi, Yasufumi Sato.　
Puromycin insensitive leucyl-specific aminopeptidase (PILSAP) is involved in the activation of endothelial integrins.
Journal of Cellular Physiology Volume193, Issue2, Date:November 2002, Pages:253-262

Hiratsuka, S., Nakamura, K., Iwai, S., Murakami, M., Itoh, T., Kijima, H., Shipley, J. M., Senior, R. M., and Shibuya, M.
Involvement of MMP9 induction by Vascular Endothelial Growth Factor Receptor-1 in lung specific metastasis
Cancer Cell 2, 289-300, 2002  

2001年

Maru, Y., K. Hanks, S.K., and Shibuya, M. The tubulogenic activity associated with an activated form of Flt-1 kinase is dependent on focal adhesion kinase.
Mol. Cell Res., Biochim. et Biophy. Acta, 1540: 147-153, 2001.

Hiratsuka, S., Maru, Y., Noda, T., and Shibuya, M. The tyrosine kinase domain of Flt-1 (vascular endothelial growth factor receptor-1) is required for tumor angiogenesis.
Cancer Res. 61: 1207-1213, 2001.

Itoh, Y., Takamura, A., Itoh, N., Maru, Y., Sato, H., Suenaga, N., Aoki, T., and Seiki, M.
Homophilic complex formation of MT1-MMP facilitates proMMP-2 activation on the cell surface and promotes tumor cell invasion.
EMBO J. 20: 4782-4793, 2001.

Maru, Y., Bergmann, E., Coin, F., Egly, J-M., and Shibuya, M.
TFIIH functions are altered by the P210BCR-ABL oncoprotein produced on the Philadelphia chromosome.
Mutation Res., 483, 83-88, 2001.

Kin, Y., Li, G., Shibuya, M., and Maru, Y.
The Dbl-homology domain of BCR is not a simple spacer in P210BCR-ABL of the Philadelphia chromosome.
J. Biol. Chem., 276, 39462-39468, 2001.

Secreted Abeta does not mediate neurotoxicity by antibody-stimulated amyloid precursor protein.
Biochem Biophys Res Commun, 282(2):548-56, 2001

2000年

Tsukahara, F., Yoshioka, T. and Muraki, T.
Molecular and functional characterization of HSC54, a novel variant of human heat-shock cognate protein 70.
Mol. Pharmacol. 58(6), 1257-1263, 2000

Yoshioka, T., Iwamoto, N., Tsukahara, F., Irie, K., Urakawa, I. and Muraki, T.
Anti-NO action of carvedilol in cell-free system and in vascular endothelial cells.
Br. J. Pharmacol. 129(7), 1530-1535, 2000

Mizushima, K., Miyamoto, Y., Tsukahara, F. Hirai, M., Sakaki, Y. and Ito, T.
A novel G-protein-coupled receptor gene expressed in striatum.
Genomics 69(3), 314-321, 2000

Sudo H. et al.
Antibody-regulated neurotoxic function of cell-surface beta-amyloid precursor protein.
Mol Cell Neurosci, 16(6), 708-23, 2000

1999年

Choi Dong-Kug, Ito, T., Tsukahara, F., Hirai, M. and Sakaki, Y.
Developmentally-regulated expression of mNapor encoding an apoptosis-induced ELAV-type RNA binding protein.
Gene 237(1), 135-142, 1999

1998年

Tsukahara, F. Urakawa, I., Hattori, M., Hirai, M., Ohba, K. Yoshioka, T., Sakaki, Y. and Muraki, T.
Molecular characterization of the mouse mtprd gene, a homologue of human TPRD: unique gene expression suggesting its critical role in the pathophysiology of Down syndrome.
J. Biochem. 123(6), 1055-1063, 1998 

Tsukahara, F., Uchida, Y., Ohba, K. Ogawa, A., Yoshioka, T. and Muraki, T.: The effect of acute cold exposure and norepinephrine on uncoupling protein gene expression in brown adipose tissue of monosodium glutamate-obese mice.
Jpn. J. Pharmacol. 77(3), 247-249, 1998 

Hiratsuka, S., Minowa, O., Kuno, J., Noda, T. and Shibuya, M. Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice
Proceedings of the National Academy of Sciences 95, 9349-9354, 1998

Kondo, K., Hiratsuka, S., Subbalakshmi, E., Matsushime, H. and Shibuya, M.
Genomic organization of the flt-1 gene encoding for Vascular Endothelial Growth Factor (VEGF) Receptor-1 suggests an intimate evolutionary relationship between the 7-Ig and the 5-Ig tyrosine kinase receptors
Gene 208, 297-305, 1998

Irie, K., Tsukahara, F., Fujii, E., Uchida, Y., Yoshioka, T., He, W.-R., Shitashige, M., Murota, S., Muraki, T.: Induction of cationic amino acid transporter-2 mRNA by tumor necrosis factor-a is associated with nitric oxide production in human umbilical vein endothelial cells. The Biology of Nitric Oxide Pt 6 (S. Moncada et al eds) p196 (1998)

1997年

Tsukahara, F., Uchida, Y., Ohba, K., Nomoto, T. and Muraki, T.
Defective stimulation of thyroxine 5'-deiodinase activity by cold exposure and norepinephrine in brown adipose tissue of monosodium glutamate-obese mice.
Horm. Metab. Res. 29(10), 496-500, 1997 

Hattori, M., Tsukahara, F., Furuhata, Y., Tanahashi, H., Hirose, M., Saito, M., Tsukuni, S. and Sakaki, Y.
A novel method for making nested deletions and its application for sequencing of a 300 kb region of human APP locus.
Nucleic. Acids. Res. 25(9), 1802-1808 (1997) 

Ohba, K., Tsukahara, F., Uchida, Y., Ogawa, A. and Muraki, T.
Iodothyronine deiodinases in a mammalian hibernator, the chipmunk (Tamias asiaticus).
Comp. Biochem. Physiol. 118C(3), 391-396 (1997)

Uchida, Y., Tsukahara, F., Ohba, K., Ogawa, A., Irie, K., Fujii, E., Yoshimoto, T., Yoshioka, T. and Muraki, T.
Nitric oxide mediates down regulation of lipoprotein lipase activity induced by tumor necrosis factor-a in brown adipocytes.
Eur. J. Pharmacol. 335(2・3), 235-243 (1997) 

Irie, K., Tsukahara, F., Fujii, E., Uchida, Y., Yoshioka, T., He Wen Rong, Shitashige, M., Murota, S. and Muraki, T.: Cationic amino acid transporter-2 mRNA induction by tumor necrosis factor-a in vascular endothelial cells.
Eur. J. Pharmacol. 339(2), 289-293 (1997) 

Uchida Y., Tsukahara F., Ohba K., Ogawa A., Nomoto T., Muraki T.
Augmentation of tumor necrosis factor-alpha-induced suppression of lipoprotein lipase by nitric oxide donors in cultured brown adipocytes.
Ann. New York Acad. Sci. 813, 369-72, (1997)  

1996年

Tsukahara, F., Hattori, M., Muraki, T. and Sakaki, Y.
Identification and cloning of a novel cDNA belonging to tetratricopeptide repeat gene family from Down syndrome-critical region 21q22.2.
J. Biochem. 120(4), 820-827 (1996)

Hiratsuka, S., Yoshida, A. and Kimata, H. Enhancement of in vitro spontaneous IgE production by topical steroid in patients with atopic dermatitis
Journal of Allergy and Clinical Immunology 98, 107-113 (1996)

Fujii, E., Irie, K., Uchida, Y., Tsukahara, F., Ohba, K., Ogawa, A. and Muraki, T.
Tolerance to lipopolysaccharide-induced increase in vascular permeability in mouse skin.
Eur. J. Pharmacol. 313(1・2), 129-134 (1996)  

1995年

Uchida, Y., Irie, K., Tsukahara, F., Ohba, K., Ogawa, A., Fujii, E. and Muraki, T.: Endothelin-1, but not endothelin-3, suppresses lipoprotein lipase gene expression in brown adipocytes differentiated in culture.
Eur. J. Pharmacol., Mol. Pharmacol. Section 291(1), 33-41 (1995)

1994年

Kimata, H. and Hiratsuka, S.
Effect of topical cromoglycate solution on atopic dermatitis: combined treatment of sodium cromoglycate solution with the oral anti-allergic medication, oxatomide
European Journal of Pediatrics 153, 66-71 (1994)　　

Uchida, Y., Tsukahara, F., Irie, K., Nomoto, T. and Muraki, T.
Possible involvement of L-arginine-nitric oxide pathway in modulating regional blood flow to brown adipose tissue of rats.
Naunyn. Schmiedebergs. Arch. Pharmacol. 349(2), 188-193 (1994) 

Muraki, T., Uchida, Y., Tsukahara, F., Ohba, K. and Mannno, S.
The effect of acute reserpine administration on the unconpling protein mRNA levels in the mouse brown adipose tissue.
Hormone Metabolic Res. 10(26), 494-495 (1994)

Fujii, E., Irie, K., Uchida, Y., Tsukahara, F. and Muraki, T.
Possible role of nitric oxide in 5-hydroxytryptamine-induced increase in vascular permeability in mouse skin. Naunyn.
Schmiedebergs. Arch. Pharmacol. 350(4), 361-364 (1994) 

Uchida, Y., Irie, K., Tsukahara, F., Ohba, K., Nomoto, T., Muraki, T.
Effect of tumor necrosis factor on the lipoprotein lipase gene expression in brown adipocytes differentiated in culture. Thermal Balance in Health and Disease, Advances in Pharmacological Sciences 1st ed (Zeisberger E et al eds) 121-127, 1994

1992年

Tsukahara, F., Shibata, Y., Muraki, T. and Nomoto, T.
Impairment of cold-induced increase in thyroxine 5'-deiodinase activity in mouse brown adipose tissue by the intracerebroventricular administration of bombesin.
Peptides 13, 129-132, 1992 

1991年

Muraki, T., Tsukahara, F., Fujii, E. and Nomoto, T
a1-Adrenergic stimulation of iodide organification in mouse thyroid: Inhibition by protein kinase C inhibitors.
Arch. int. Pharmacodyn. Ther. 314, 122-132, 1991

1990年

Tsukahara, F., Muraki, T. and Nomoto, T.
Serum concentrations of thyroid hormones and activity of iodothyronine deiodinase in peripheral tissues of the house musk shrew, Suncus murinus.
J. Endocrinol. 125, 117-122, 1990

1989年

Muraki, T., Tsukahara, F., Oike, N. and Nomoto, T.
Effect of reserpine pretreatment on brown fat iodothyronine 5'-deiodinase of mouse.
J. Pharm. Pharmacol. 41, 499-501, 1989

Tsukahara F., Nomoto T., Maeda, M.
Properties of 5'-deiodinase of 3,3',5'-triiodothyronine in rat skeletal muscle.
Acta Endocrinol. 120, 69-74, 1989

1986年

Adachi, T., Maeda, M., Nomoto T., Tsukahara F., Sakamoto, S., Takeda, Y.
In vitro study on thyroid hormone metabolism of human placenta in early pregnancy.
Asia-Oceania J.Obstet.Gynaecol. 12, 385-393, 1986

1982年

Fujii, E., Tsukahara, F., Nomoto, T.
Effects of nicotinamide and insulin on glycosylated hemoglobin and blood glucose in thyroidectomized streptozotocin-diabetic rats.
Japan. J. Pharmacol.32, 903-907, 1982