2018年の研究業績

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原著論文 | 総説等 | 著書 | 新聞 | 受賞

2018 原著論文 / Original Papers →女子医大業績データベース

  1. HARAGUCHI Yuji†, KAGAWA Yuki, HASEGAWA Akiyuki, KUBO Hirotsugu, SHIMIZU Tatsuya*, “Rapid fabrication of detachable three-dimensional tissues by layering of cell sheets with heating centrifuge”, Biotechnology Progress, 34(3):692-701(2018/01)
  2. Niimi Yosuke†, Matsumine Hajime*, Takeuchi Yuichi, Osaki Hironobu, Tsunoda Satoshi, Miyata Mariko, Yamato Masayuki, Sakurai Hiroyuki, “A collagen-coated PGA conduit for interpositional-jump graft with end-to-side neurorrhaphy for treating facial nerve paralysis in rat.”, Microsurgery, Epub ahead of print(2018/01)
  3. KIM Seong-Ryong†, YI Hye-jin, LEE Yu Na, PARK Ji Yoon, HOFFMAN Robert, OKANO Teruo, SHIM In Kyong*, KIM Song Cheol*, “Engineered mesenchymal stem-cell-sheets patches prevents postoperative pancreatic leakage in a rat model”, Scientific Reports, 8:360(2018/01)
  4. Zhao Ye-Li†, Lu Zhuo-Yu, Zhang Xuan, Liu Wei-Wei, Yao Guo-Dong, Liu Xiao-Ling, Liu Wei, Wu Qing-Jie, Hayashi Toshihiko, Yamato Masayuki, Fujisaki Hitomi, Hattori Shunji, Atsuzawa Yuji, Tashiro Shin-Ichi, Onodera Satoshi, Ikejima Takashi*, “Gelatin promotes cell aggregation and pro-inflammatory cytokine production in PMA-stimulated U937 cells by augmenting endocytosis-autophagy pathway.”, The international journal of biochemistry & cell biology, 95:132-142(2018/01)
  5. AKIMOTO Jun†, NAKAYAMA Masamichi*, TAKAGI Soichi, OKANO Teruo*, “Improved In Vivo Subcutaneous Tumor Generation by Cancer Cell Sheet Transplantation”, Anticancer Research, 38(2):671-676(2018/02)
  6. OHYA Takashi†, NAKAZONO Kazuki, KIKUCHI Tetsutaro, SASAKI Daisuke, SAKAGUCHI Katsuhisa, SHIMIZU Tatsuya, FUKUDA Kenjiro, SOMEYA Takao, UMEZU Shinjiro*, “Simple action potential measurement of cardiac cell sheet utilizing electronic sheet”, Artificial Life and Robotics, 1-7(2018/03)
  7. Utoh Rie†, Komori Junji, Kuge Hiroyuki, Tatsumi Kohei, Yamada Masumi, Hirohashi Shinji, Tsutsumi Masahiro, Amanuma Toshihiro, Yoshioka Akira, Nakajima Yoshiyuki, Wake Kenjiro, Okano Teruo, Lagasse Eric, Ohashi Kazuo*, “Adult hepatocytes direct liver organogenesis through non-parenchymal cell recruitment in the kidney.”, Journal of hepatology, 68(4):744-753(2018/04)
  8. Liu Xiaoling†, Xu Qian, Liu Weiwei, Yao Guodong, Zhao Yeli, Xu Fanxing, Hayashi Toshihiko, Fujisaki Hitomi, Hattori Shunji, Tashiro Shin-Ichi, Onodera Satoshi, Yamato Masayuki, Ikejima Takashi*, “Enhanced Migration of murin fibroblast-like 3T3-L1 preadipocytes on type I collagen-coated dish is reversed by silibinin treatment.”, Molecular and cellular biochemistry, 441(1-2):35-62(2018/04)
  9. Liu Xiaoling†, Long Xinyu, Liu Weiwei, Yao Guodong, Zhao Yeli, Hayashi Toshihiko, Hattori Shunji, Fujisaki Hitomi, Ogura Takaaki, Tashiro Shin-Ichi, Onodera Satoshi, Yamato Masayuki, Ikejima Takashi*, “Differential levels of reactive oxygen species in murine preadipocyte 3T3-L1 cells cultured on type I collagen molecule-coated and gel-covered dishes exert opposite effects on NF-κB-mediated proliferation and migration.”, Free radical research, Epub ahead of print(2018/05)
  10. KOBAYASHI Jun†*, ARISAKA Yoshinori, YUI Nobuhiko, AKIYAMA Yoshikatsu, YAMATO Masayuki, OKANO Teruo, “Effect of temperature changes on serum protein adsorption on thermoresponsive cell-culture surfaces monitored by a quartz crystal microbalance with dissipation”, International Journal of Molecular Sciences, 19(5):1516(2018/05)
  11. XU Qian†, LIU Xiaoling, LIU Weiwei, HAYASHI Toshihiko, YAMATO Masayuki, FUJISAKI Hitomi, HATTORI Shunji, TASHIRO Shin-Ichi, ONODERA Satoshi, IKEJIMA Takashi*, “Type I collagen-induced YAP nuclear expression promotes primary cilia growth and contributes to cell migration in confluent mouse embryo fibroblast 3T3-L1 cells.”, Molecular and cellular biochemistry, 1-10(2018/05)
  12. Homma Jun, Sekine Hidekazu, Matsuura Katsuhisa, Kobayashi Eiji, Shimizu Tatsuya, “Mesenchymal stem cell sheets exert anti-stenotic effects in a rat arterial injury model.”, Tissue engineering. Part A, Epub ahead of print-‐(2018/05)
  13. MASUDA Shinako†, MATSUURA Katsuhisa*, SHIMIZU Tatsuya, “Inhibition of LYPD1 is critical for endothelial network formation in bioengineered tissue with human cardiac fibroblasts”, Biomaterials, 166:109-121(2018/06)
  14. Erika L. Cyphert†, Horst A. von Recum, Masayuki Yamato,Masamichi Nakayama*, “Surface sulfonamide modification of poly(N-isopropylacrylamide)-based block copolymer micelles to alter pH and temperature responsive properties for controlled intracellular uptake”, Journal of Biomedical Materials Research Part A, 106(6):1552-1560(2018/06)
  15. AKIMOTO Jun†, ITO Yoshihiro, OKANO Teruo, NAKAYAMA Masamichi*, “Controlled aggregation behavior of thermoresponsive polymeric micelles by introducing hydrophilic segments as corona components”, Journal of Polymer Science Part A, 56:1695-1704(2018/06)
  16. LIU Xiaoling†, XU Qian, LONG Xinyu, LIU Weiwei, ZHAO Yeli, HAYASHI Toshihiko, HATTORI Shunji, FUJISAKI Hitomi, OGURA Takaaki, TASHIRO Shin-Ichi, ONODERA Satoshi, YAMATO Masayuki, IKEJIMA Takashi*, “Silibinin-induced autophagy mediated by PPARα-sirt1-AMPK pathway participated in the regulation of type I collagen-enhanced migration in murine 3T3-L1 preadipocytes.”, Molecular and cellular biochemistry, 1-23(2018/06)
  17. FUJITA Izumi†, UTOH Rie, YAMAMOTO Masakazu, OKANO Teruo, YAMATO Masayuki*, “The liver surface as a favorable site for islet cell sheet transplantation in type 1 diabetes model mice”, Regenerative Therapy, 8:65-72(2018/06)
  18. SAKAGUCHI Katsuhisa†, HINATA Yuto, KAGAWA Yuki, IWASAKI Kiyotaka, TSUNEDA Satoshi, SHIMIZU Tatsuya*, UMEZU Mitsuo, “Low-temperature culturing improves survival rate of tissue-engineered cardiac cell sheets”, Biochemistry and Biophysics Reports, 14:89-97(2018/07)
  19. Liu Xiaoling†, Long Xinyu, Liu Weiwei, Zhao Yeli, Hayashi Toshihiko, Yamato Masayuki, Mizuno Kazunori, Fujisaki Hitomi, Hattori Shunji, Tashiro Shin-Ichi, Ogura Takaaki, Atsuzawa Yuji, Ikejima Takashi*, “Type I collagen induces mesenchymal cell differentiation into myofibroblasts through YAP-induced TGF-β1 activation.”, Biochimie, 150:110-130(2018/07)
  20. HARAGUCHI Yuji†, MATSUURA Katsuhisa, KAGAWA Yuki, HASEGAWA Akiyuki, KUBO Hirotsugu, SHIMIZU Tatsuya*, “Rapid creation system of morphologically and functionally communicative three-dimensional cell-dense tissue by centrifugation.”, Biotechnology progress, Epub ahead of print(2018/07)
  21. KURAMOTO Goro†, SHIMIZU Tatsuya*, TAKAGI Soichi, ISHITANI Ken, MATSUI Hideo, OKANO Teruo, “Endometrial regeneration using cell sheet transplantation techniques in rats facilitates successful fertilization and pregnancy.”, Fertility and sterility, 110(1):172-181.e4(2018/07)
  22. Pak Sehyung†, Hwang Sung Wook, Shim In Kyong, Bae Sang Mun, Ryu Yeon- Mi, Kim Han-Byul, Do Eun-Ju, Son Hye-Nam, Choi Eun-Ji, Park Sun-Ha, Kim Sang-Yeob, Park Sang Hyoung, Ye Byong Duk, Yang Suk-Kyun, Kanai Nobuo, Maeda Masanori, Okano Teruo, Yang Dong-Hoon*, Byeon Jeong-Sik*, Myung Seung-Jae*, “Endoscopic Transplantation of Mesenchymal Stem Cell Sheets in Experimental Colitis in Rats.”, Scientific reports, 8(1):11314(2018/07)
  23. TANI Yoshiki†, SATO Masato*, YOKOYAMA Munetaka, YOKOYAMA Miuiki, TAKAHASHI Takuni, TOYODA Eriko, OKADA Eri, FUJIMURA Shinsei, MURAKI Hideyuki, KATO Yoshiharu, YAMATO Masayuki, OKANO Teruo, MOCHIDA Joji, “Intra-articular administration of EP2 enhances the articular cartilage repair in a rabbit model”, Journal of Tissue Engineering and Regenerative Medicine, Epub ahead of print(2018/08)
  24. WASHIO Kaoru†,TSUTSUMI Yusuke, TSUMANUMA Yuka, YANO Kosei, SRITHANYARAT Supreda Suphanantachat, TAKAGI Ryo, ICHINOSE Shizuko, MEINZER Walter, YAMATO Masayuki, OKANO Teruo, HANAWA Takao, ISHIKAWA Isao*, “In vivo periodontium formation around titanium implants using periodontal ligament cell sheet”, Tissue Engineering Part A, 24(15-16):1273-1282(2018/08)
  25. ISHIDA Masaru†, MIYAGAWA Shigeru, SAITO Atsuhiro, FUKUSHIMA Satsuki, HARADA Akima, ITO Emiko, OHASHI Fumiya, WATANABE Tadashi, HATAZAWA Jun, MATSUURA Katsuhisa, SAWA Yoshiki, “Transplantation of human induced pluripotent stem cell-derived cardiomyocytes is superior to somatic stem cell therapy for restoring cardiac function and oxygen consumption in a porcine model of myocardial infarction.”, Transplantation, Epub ahead of print(2018/08)
  26. AKIYAMA Yoshikatsu†*, MATSUYAMA Miki, YAMATO Masayuki, TAKEDA Naoya, OKANO Teruo*, “Poly(N-isopropylacrylamide)-Grafted Polydimethylsiloxane Substrate for Controlling Cell Adhesion and Detachment by Dual Stimulation of Temperature and Mechanical Stress”, Biomacromolecules, 19(10):4014-4022(2018/09)
  27. TAKAHASHI Hironobu†, SHIMIZU Tatsuya, OKANO Teruo, “Engineered human contractile myofiber sheets as a platform for studies of skeletal muscle physiology”, Scientific Reports, 8(1):13932(2018/09)
  28. Matsuura Katsuhisa†, Hagiwara Nobuhisa, SHIMIZU Tatsuya, “iPS cell elimination in a cell sheet by methionine-free and 42 °C condition for tumor prevention”, Tissue Engineering Part C: Methods, Epub ahead of print(2018/09)
  29. Moritani Y†, Usui M*, Sano K, Nakazawa K, Hanatani T, Nakatomi M, Iwata T, Sato T, Ariyoshi W, Nishihara T, Nakashima K., “Spheroid culture enhances osteogenic potential of periodontal ligament mesenchymal stem cells.”, Journal of periodontal research, 53(5):870-882(2018/10)
  30. KIKUCHI Tetsutaro†, KINO-OKA Masahiro, WADA Masanori, KOBAYASHI Toyoshige, KATO Midori, TAKEDA Shizu, KUBO Hirotsugu, OGAWA Tatsuya, SUNAYAMA Hironobu, TANIMOTO Kazuhito, MIZUTANI Manabu, SHIMIZU Tatsuya*, OKANO Teruo, “A novel, flexible and automated manufacturing facility for cell-based health care products: Tissue Factory”, Regenerative Therapy, 9:89-99(2018/12)
  31. IWATA Takanori†*, YAMATO Masayuki, WASHIO Kaoru, YOSHIDA Toshiyuki, TSUMANUMA Yuka, YAMADA Azusa, ONIZUKA Satoru, ISHIKAWA Isao, ANDO Tomohiro, OKANO Teruo*, IZUMI Yuichi, “Periodontal regeneration with autologous periodontal ligament-derived cell sheets - A safety and efficacy study in ten patients”, Regenerative Therapy, 9:38-44(2018/12)
  32. MASUDA Shinako†, MATSUURA Katsuhisa*, SHIMIZU Tatsuya, “Preparation of iPS cell-derived CD31+ endothelial cells using three-dimensional suspension culture”, Regenerative Therapy, 9:1-9(2018/12)

2018 総説等 / Review Papers →女子医大業績データベース

  1. NAGASE Kenichi†*, YAMATO Masayuki, KANAZAWA Hideko, OKANO Teruo*, “Poly(N-isopropylacrylamide)-based thermoresponsive surfaces provide new types of biomedical applications”, Biomaterials, 153:27-48(2018/01)
  2. 松浦勝久†*, “再生医療用ヒト心筋組織開発”, 再生医療, 17(1):90-97(2018/02)
  3. 岩田 隆紀, “間葉系幹細胞を用いた再生医療”, 未来医学, 31:79-83(2018/02)
  4. 原口裕次, 清水達也, “藻類と動物細胞の共生リサイクル培養による立体心筋組織の作製”, バイオサイエンスとインダストリー, 76(2):136-138(2018/03)
  5. 秋山義勝, 岡野光夫, “細胞シート工学を支える温度応答性細胞培養表面の設計と特性”, 高分子論文集, 75(2):174-186(2018/03)
  6. 鬼塚 理†, 岩田 隆紀*, “細胞シートを用いた歯周組織の再生”, , 43(2):56-62(2018/03)
  7. 中山正道†, 清水達也, “神経芽細胞腫の灌流培養組織モデルを利用した薬物耐性機序の解析”, バイオマテリアル, 36(3):234-235(2018/07)
  8. 松浦勝久†, “心不全治療のための補助循環を目指した移植用心筋組織開発”, 循環器専門医, 27:9-18(2018/08)
  9. KOMAE Hyoe†, ONO Minoru, SHIMIZU Tatsuya*, “Cell Sheet-Based Vascularized Myocardial Tissue Fabrication.”, European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes, 59(3-4):276-285(2018/09)
  10. Matsuura Katsuhisa†, “Toward the Development of Novel Therapy for Hypertrophic Cardiomyopathy”, International Heart Journal, 59(5):914-916(2018/09)
  11. 大和雅之, “巻頭言「未承認再生医療提供問題」の解決と国民の啓発は学会の義務である”, 再生医療, 17(3):1-1(2018/08)

2018 著書 / Books →女子医大業績データベース

  1. 大和雅之, "第2章 ものづくりとしての細胞シート工学", ものづくり技術からみる再生医療 -細胞研究・創薬・治療-, , シーエムシー出版, 普及版,109-116(2018/03)
  2. 清水達也, 菊地鉄太郎, "細胞シート工学を基盤とした立体臓器製造技術", 再生医療・創薬のための3次元細胞培養技術, 紀ノ岡正博, シーエムシー出版, 8-19(2018/04)
  3. 大和雅之, "ティッシュ・エンジニアリング研究最前線", 先進医療NAVIGATOR 再生医療・細胞医療の研究と産業化の最前線, 先進医療フォーラム, 日本医学出版, 初版,10-13(2018/07)
  4. 岩田隆紀, 鬼塚理, "歯周組織・顎骨の再生治療の最先端研究と今後の課題", 先進医療 NAVIGATOR 再生医療・細胞医療の研究と産業化の最前線, 先端医療フォーラム, 日本医学出版, 初,76-79(2018/07)
  5. NAGASE Kenichi, YAMATO Masayuki, OKANO Teruo, "Temperature-responsive Polymers for Tissue Engineering", Temperature-Responsive Polymers: Chemistry, Properties, and Applications, Vitaliy V. Khutoryanskiy, Theoni K. Georgiou, John Wiley & Sons, 301-312(2018/07)

2018 新聞 / Newspaper

  1. 2018.9.12 苫小牧民報 7面
    貝淵信之:“抜歯後に顎骨壊死 骨粗しょう症治療薬の副作用”
  2. 2018.9.24 十勝毎日新聞 23面
    貝淵信之:“抜歯の後に顎骨壊死 骨粗しょう症治療薬に副作用”
  3. 2018.10.5 日経バイオテク法人版ONLINE 
    岩田隆紀:“東京女子医大、他家歯根膜由来MSCの細胞シートの医師主導治験を開始 -重度の歯周炎患者6例を対象に移植する予定-”

2018 受賞 / Awards

  1. 東京女子医科大学学会, 平成29年度佐竹高子研究奨励賞, 2018.2.24
     青木信奈子 “新規血管新生抑制因子LYPD1の機能部位の同定”
  2. 文部科学省 第7回サイエンス・インカレ, 科学技術振興機構理事長賞, 2018.3.4
     上本詩織 “藻類・動物細胞を用いた新規組織共培養法確立のための基礎検討”
  3. 第26回日本有病者歯科医療学会学術大会, 発表優秀賞, 2018.3.5
     貝淵信之 “ビスフォスフォネートを投与したビーグル犬顎骨における他家間葉系幹細胞シート移植による創傷治癒の改善”
  4. 第43回日本脳卒中学会学術集会, 優秀口演賞, 2018.3.16
     劉 美憬 “ペリサイト含有間葉系幹細胞シートを用いた脳梗塞モデルに対する細胞療法研究”
  5. 日本材料科学会, 若手奨励賞(ポスター発表部門), 2018.5.31
     秋元 渓 “異なる径の管腔構造を有する生体組織の作製”
  6. TWIns10周年記念シンポジウム, ポスター賞(女子医大), 2018.6.2
     中園一紀 “生体接着剤を用いた細胞シート高速積層技術による立体心筋組織の構築究”
  7. TWIns10周年記念シンポジウム, ポスター賞(女子医大), 2018.6.2
     上本詩織 “藻類・動物細胞共生リサイクル培養による三次元組織作製”
  8. 日本画像学会, 研究奨励賞, 2018.6.19
     大矢貴史 “エレクトロニクスシートを用いた生体電位計測のための基礎的研究”
  9. 日本画像学会創立60周年記念懸賞論文 佳作, 2018.6.19
     大矢貴史 “次世代医療技術のための画像形成技術に寄るスマートデバイスの創生”
  10. 日本機械学会, 2018年茨城講演会, 優秀講演発表賞, 2018.8.22
     大矢貴史 “フレキシブルエレクトロニクスの電極組成が細胞生存率に与える影響の評価”
  11. 第25回材料科学若手研究者討論会, プレゼンテーション賞, 2018.9.5
     大矢貴史 “電気シグナルの検出が可能な薄膜バイオセンサの開発”
  12. 5th TERMIS World Congress 2018, 2018 TERMIS-AP Excellence Achievement Award, 2018.9.7
     Teruo Okano
  13. 5th TERMIS World Congress 2018, TERMIS-WC 2018 SYIS Oral Presentation Award 2nd Place, 2018.9.7
     Yusuke Tobe “Fabrication of a human implantable vascular bed using decellularized porcine small intestine re-endothelialized with human cells”