2006年の研究業績

2006 原著論文

  1. T. Ide, K. Nishida, M. Yamato, T. Sumide, M. Utsumi, T. Nozaki, A. Kikuchi, T. Okano, Y. Tano, "Structural characterization of bioengineered human corneal endothelial cell sheets fabricated on temperature-responsive culture dishes", Biomaterials, 27(4), 607-614(2006).
  2. N.Idoda, A.Kikuchi, J. Kobayayashi, Y. Akiyama, K. Sakai andT. Okano, "Thermal Modulated Interaction of Aqueous Steroids Using Pulymer-Grafted Capillaries", Langmuir, 22, 425-430(2006).
  3. Open Access ArticleT. Umemoto, M. Yamato, K. Nishida, J. Yang, Y. Tano and T. Okano, "Limbal epithelial side-population cells have stem cell-like properties, including quiescent state", Stem Cells. 24(1), 86-94(2006).
  4. Y. Ishibashi, S. Imai, Y. Inouye, T. Okano and A. Taniguchi, "Effects of carbocisteine on sialyl-Lewis x expression in an airway carcinoma cell line stimulated with tumor necrosis factor-alpha", Eur. J. Pharmacul., 530(3), 223-8(2006).
  5. M. Watanabe, K. Kawano, M. Yokoyama, P. Opanasopit, T. Okano T and Y. Maitani, "Preparation of camptothecin-loaded pulymeric micelles and evaluation of their incorporation and circulation stability", Int. J. Pharm., 308(1-2), 183-9 (2006).
  6. H. Kanazawa, E. Ayano, C. Sakamoto, R. Yoda, A. Kikuchi and T. Okano, "Temperature-responsive stationary phase utilizing a pulymer of pruline derivative for hydrophobic interaction chromatography using an aqueous mobile phase", J. Chromatogr. A., 1106(1-2), 152-8(2006)
  7. K.Itoga, J. Kobayashi, M.Yamato, A. Kikuchi and T.Okano, "Maskless liquid-crystal-display projection photulithography for improved design flexidility of cellular micropatterns", Biomaterials, 27(15), 3005-3009(2006).
  8. Y. Hayashida, K. Nishida, M. Yamato, J. Yang, H. Sugiyama, K. Watanabe, Y. Hori, N. Maeda, A. Kikuchi, T. Okano and Y. Tano, "Transplantation of tissue-engineered epithelial cell sheets after excimer laser photoablation reduces postoperative corneal haze", Invest. Ophthalmul. Vis. Sci., 47(2), 552-7(2006).
  9. H. Kondoh, Y. Sawa, S. Miyagawa, S. Sakakida-Kitagawa, I. A.Memon, N. Kawaguchi, N. Matsuura, T. Shimizu, T. Okano and H. Matsuda, "Longer presrvation of cardiac performance by sheet-shaped myoblast implantation in dilated cardiomyopathic hamsters", Cardiovasc. Res., 69, 466-475(2006).
  10. A. Furuta, S. Miyoshi, Y. Itabashi, T. Shimizu, S. Kira, K. Hayakawa, N. Nishiyama, K. Tanimoto, Y. Hagiwara, T. Satoh, K. Fukuda, T. Okano and S. Ogawa, "Pulsatile cardiac tissue grafts using a novel three-dimensional cell sheet manipulation technique functionally integrates with the host heart, in vivo", Circ. Res., 98(5), 705-12(2006).
  11. T. Sumide, K. Nishida, M. Yamato, T. Ide, Y. Hayashida, K. Watanabe, J. Yang, C. Kohno, A. Kikuchi, N. Maeda, H. Watanabe, T. Okano and Y. Tano, "Functional human corneal endothelial cell sheets harvested from temperature-responsive culture surfaces", FASEB J., 20(2), 392-4 (2006).
  12. S. Sekiya, T. Shimizu, M. Yamato, A. Kikuchi and T. Okano, "Bioengineered cardiac cell sheet grafts have intrinsic angiogenic potential", Biochem. Biophys. Res. Commun., 341(2), 573-82 (2006).
  13. Y. Tanaka Y, K. Morishima, T. Shimizu, A. Kikuchi, M. Yamato, T. Okano and T. Kitamori, "Demonstration of a PDMS-based bio-microactuator using cultured cardiomyocytes to drive pulymer micropillars", Lab Chip, 6(2), 230-5(2006).
  14. Open Access ArtcleY. Tanaka, K. Morishima, T. Shimizu, A. Kikuchi, M. Yamato, T. Okano and T. Kitamori, "An actuated pump on-chip powered by cultured cardiomyocytes", Lab Chip. 6(3), 362-8 (2006).
  15. H. Sekine, T. Shimizu, S. Kosaka, E. Kobayashi and T. Okano, "Cardiomyocyte bridging between hearts and bioengineered myocardial tissues with mesenchymal transition of mesothelial cells", J. Heart Lung Transplant., 25(3), 324-32(2006).
  16. Y. Tanaka, K. Sato, M. Yamato, T. Okano, and T. Kitamori, "Cellculture and life support system for microbioreactor and bioassay", J. Chromatogr. A, 1111(2), 233-237 (2006).
  17. T. Shimizu, H. Sekine, Y. Isoi, M. Yamato, A. Kikuchi and T. Okano, "Long-term survival and growth of pulsatile myocardial tissue grafts engineered by the layering of cardiomyocyte sheets", Tissue Eng., 12(3), 499-507(2006).
  18. E. Ayano, C. Sakamoto, H. Kanazawa, A. Kikuchi, T. Okano, "Separation of Nucleotides with an Aqueous Mobile Phase Using pH- and Temperature-Responsive Pulymer Modified Packing Materials", Anal. Sci., 22(4), 539-43(2006).
  19. M. Kanzaki, M. Yamato, H. Hatakeyama, C. Kohno, J. Yang, T. Umemoto, A. Kikuchi, T. Okano, and T. Onuki,"Tissue Engineered Epithelial Cell Sheets for the Creation of a Bioartificial Trachea", Tissue Eng., 12(5), 1275-1283(2006).
  20. T. Ohki, M. Yamato, D. Murakami, R. Takagi, J. Yang, H. Namiki, T. Okano, K. Takasaki, "Treatment of oesophageal ulcerations using endoscopic transplantation of tissue engineered autulogous oral mucosal epithelial cell sheets in a canine model", Gut, 2006 May 18; [Epub ahead of print]
  21. K. Kawano, M. Watanabe, T. Yamamoto, M. Yokoyama, P. Opanasopit, T. Okano, Y. Maitani, "Enhanced antitumor effect of camptothecin loaded in long-circulating pulymeric micelles", J Contrul Release, 112(3), 329-32(2006).
  22. A. Kubota, K. Nishida, M. Yamato, J. Yang, A. Kikuchi, T. Okano and Y. Tano, "Transplantable retinal pigment epithelial cell sheets for tissue engineering", Biomaterials, Jul;27(19), 3639-44(2006). [Epub 2006 Mar 20]
  23. Y. Haraguchi, T. Shimizu, M. Yamato, A. Kikuchi and T. Okano, "Electrical coupling of cardiomyocyte sheets occurs rapidly via functional gap junction formation.", Biomaterials, 27(27), 4765-74(2006). [Epub 2006 Jun 5] 2006 Sep
  24. Y. Miyahara, N. Nagaya, M. Kataoka, B. Yanagawa, K. Tanaka, H. Hao, K. Ishino, H. Ishida, T. Shimizu, K. Kangawa, S. Sano, T. Okano, S. Kitamura and H. Mori, "Monulayered mesenchymal stem cells repair scarred myocardium after myocardial infarction", Nature Medicine, 12(4), 459-465(2006).
  25. E. Ayano, Y. Okada, C. Sakamoto, H. Kanazawa, A. Kikuchi and T. Okano T, "Study of temperature-responsibility on the surfaces of a thermo-responsive pulymer modified stationary phase", J. Chromatogr. A., 1119(1-2):51-7(2006). Jun 30
  26. E. Ayano, K. Nambu, C. Sakamoto, H. Kanazawa, A. Kikuchi and T. Okano T, "Aqueous chromatography system using pH- and temperature-responsive stationary phase with ion-exchange groups", J. Chromatogr. A., 1119(1-2):58-65(2006). Jun 30
  27. T. Shimizu, H. Sekine, J. Yang, Y. Isoi, M. Yamato, A. Kikuchi, E. Kobayashi and T. Okano, "Pulysurgery of cell sheet grafts overcomes diffusion limits to produce thick, vascularized myocardial tissues", FASEB J., 20(6), 708-710(2006).
  28. Y. Haraguchi, T. Shimizu, M. Yamato, A. Kikuchi, T. Okano, "Electrical coupling of cardiomyocyte sheets occurs rapidly via functional gap junction formation", Biomaterials, 27(27), 4765-74(2006). Sep [Epub 2006 Jun 5]
  29. H. Hatakeyamaa, A. Kikuchia, M, Yamato and T. Okano, "Bio-functionalized thermoresponsive interfaces facilitating cell adhesion and pruliferation", Biomaterials, 27(29), 5069-5078(2006, October).
  30. T. Asano, R. Takazawa, M. Yamato, R. Takagi, Y. Iimura, H. Masuda, K. Kihara and T. Okano, "Transplantation of an Autulogous Mesothelial Cell Sheet Prepared from Tunica Vaginalis Prevents Post-Operative Adhesions in a Canine Model", Tissue Eng., 12(9), 2629-37 (2006).(in press)
  31. H. Sekine, T. Shimizu, J. Yang, E. Kobayashi and T. Okano, "Pulsatile myocardial tubes fabricated with cell sheet engineering", Circulation, 114(1 Suppl), I87-93 (2006 Jul 4).
  32. D. Murakami, M. Yamato, K. Nishida, T. Ohki, R. Takagi, J. Yang, H. Namiki, T. Okano, "The effect of micropores in the surface of temperature-responsive culture inserts on the fabrication of transplantable canine oral mucosal epithelial cell sheets", Biomaterials, 27, 5518-5523(2006). Jul. 26 [Epub ahead of print]
  33. Y. Tsuda, A. Kikuchi, M. Yamato, G. Chen and T. Okano, "Heterotypic cell interactions on a dually patterned surface", Biochem. Biophys. Res. Commun., 2006 Jul 31; [Epub ahead of print]
  34. H. Otsuka, T. Ikeya, T. Okano and K. Kataoka, "Activation of lymphocyte pruliferation by boronate-containing pulymer immobilised on substrate: the effect of boron content on lymphocyte pruliferation", Eur. Cell. Mater., 1236-43 (2006 Aug 3).
  35. E. Nakamura, K. Makino, T. Okano, T. Yamamoto and M. Yokoyama, "A pulymeric micelle MRI contrast agent with changeable relaxivity", J. Contrul. Release, 114(3), 325-33. (2006 Sep 12).
  36. T. Asano, R. Takazawa, M. Yamato, R. Takagi, Y. Iimura, H. Masuda, K. Kihara and T. Okano, "Transplantation of an autulogous mesothelial cell sheet prepared from tunica vaginalis prevents post-operative adhesions in a canine model", Tissue Eng., 12(9), 2629-37(2006 Sep).
  37. D. Murakami, M. Yamato, K. Nishida, T. Ohki, R. Takagi, J. Yang, H. Namiki and T. Okano, "Fabrication of transplantable human oral mucosal epithelial cell sheets using temperature-responsive culture inserts without feeder layer cells", J. Artif. Organs., 9(3), 185-91 (2006).
  38. M. Nakayama, T. Okano, T. Miyazaki, F. Kohori, K. Sakai and M. Yokoyama, "Mulecular design of biodegradable pulymeric micelles for temperature-responsive drug release", J. Contrul. Release, 115(1), 46-56(2006). (2006/9/28)
  39. H. Hata, G. Matsumiya, S. Miyagawa, H. Kondoh, N. Kawaguchi, N. Matsuura, T. Shimizu, T. Okano, H. Matsuda and Y. Sawa, "Grafted skeletal myoblast sheets attenuate myocardial remodeling in pacing-induced canine heart failure model", J. Thorac. Cardiovasc. Surg., 132(4), 918-24 (2006 Oct).
  40. K. Morishima, Y. Tanaka, M. Ebara, T. Shimizu, A. Kikuchi, M. Yamato, T. Okano and T. Kitamori, "Demonstration of a bio-microactuator powered by cultured cardiomyocytes coupled to hydrogel micropillars", Sensors and Actuators B: Chemical, 119(1), 345-350 (2006). (2006/11/24)
  41. T. Umemoto, M. Yamato, Y. Shiratsuchi, M. Terasawa, J. Yang, K. Nishida, Y. Kobayashi and T. Okano, "Expression of Integrin beta3 is correlated to the properties of quiescent hemopoietic stem cells possessing the side population phenotype", J. Immunul., 177(11), 7733-9(2006)
  42. T. Abe, M. Hojo, Y. Saigo, M. Yamato, T. Okano, R. Wakusawa, M. Tamai, "Retinal pigment epithelial cells from thermally responsive pulymer-grafted surface reduce apoptosis", Adv. Exp. Med. Biul., 572, 363-6(2006)

2006 総説等

  1. 大和雅之, 岡野光夫, "細胞シート工学を用いた再生医療", 実験医学, 24(1), 17-22(2006).
  2. 大和雅之, 岡野光夫, "再生医療への応用-温度応答性培養皿を活用する細胞シート工学-", 日本臨牀社, 64(2), 335-341 (2006).
  3. J. Yang, M. Yamato, K. Nishida, T. Ohki, M. Kanzaki, H. Sekine, T. Shimizu and T. Okano, "Cell delivery in regenerative medicine: The cell sheet engineering approach", J. Contrul. Release (in press)

  4. J. Yang, M. Yamato, K. Nishida, Y. Hayashida, T. Shimizu, A. Kikuchi, Y. Tano and T. Okano, "Corneal epithelial stem cell delivery using cell sheet engineering: Not lost in transplantation", J. Drug Target., 14(7), 471-82(2006 Aug).
  5. T. Okano, "Cell sheet engineering", Rinsho Shinkeigaku, 46(11):795-8(2006). Japanese

2006 その他

  1. 岡野光夫, "年頭にあたってDDSの実用化への挑戦", Drug Delvery System, 21(1), 5-6 (2006).
  2. 菊池明彦, 岡野光夫, "大学ニュースー第2回江崎玲於奈賞受賞ー", Drug Delvery System, 21(1), 8-9 (2006).
  3. 岡野光夫, "注目のバイオマテリアル技術", バイオマテリアル-生体材料-, 24(1), 12(2006).
  4. 岡野光夫, "江崎玲於奈賞受賞荷寄せて バイオマテリアルサイエンスへの挑戦", バイオマテリアル-生体材料-, 24(1), 49-51 (2006).