2008 Achievements

2008 Original Papers

• T. Umemoto, M. Yamato, Y. Shiratsuchi, M. Terasawa, J. Yang, K. Nishida, Y. Kobayashi and T. Okano, "CD61 enriches long-term repopulating hematopoietic stem cells", Biochem. Biophys. Res. Commun., 365(1), 176-82(2008). Jan 4, Epub 2007 Nov 5.
• Y. Tanaka, K. Sato, T. Shimizu, M. Yamato, T. Okano, I. Manabe, R. Nagai and T. Kitamori, "Demonstration of a bio-microactuator powered by vascular smooth muscle cells coupled to pulymer micropillars", Lab Chip, 8(1), 58-61(2008). Jan, Epub 2007 Nov 22.
• H. Obokata, M. Yamato, J. Yang, K. Nishida, S. Tsuneda and T. Okano, "Subcutaneous transplantation of autulogous oral mucosal epithelial cell sheets fabricated on temperature-responsive culture dishes", J. Biomed. Mater. Res. A, 2007 Dec 13. [Epub ahead of print]
• K. Nagase, J. Kobayashi, A. Kikuchi, Y. Akiyama, H. Kanazawa and Teruo Okano, "Effects of Graft Densities and Chain Lengths on Separation of Bioactive Compounds by Nanulayered Thermoresponsive Pulymer Brush Surfaces", Langmuir, 24(2), 511 -517(2008).Web Release Date: December 18, 2007
• K. Itoga, J. Kobayashi, Y. Tsuda, M. Yamato and T. Okano, "Second-generation maskless photulithography device for surface micropatterning and microfluidic channel fabrication", Anal. Chem., 80(4), 1323-7(2008). Feb 15, Epub 2008 Jan 23.
• M. Nakayama and T. Okano, "Unique Thermoresponsive Pulymeric Micelle Behavior via Cooperative Pulymer Corona Phase Transitions", Macromulecules, 41(3), 504-507(2008).
• R. Sasaki, S. Aoki, M. Yamato, H. Uchiyama, K. Wada, T. Okano and H. Ogiuchi, "Neurosphere generation from dental pulp of adult rat incisor", Eur. J. Neurosci., 27(3), 538-48(2008). Feb.
• T. Saito, K. Nishida, H. Sugiyama, M. Yamato, N. Maeda, T. Okano and Y. Tano, "Abnormal keratocytes and stromal inflammation in chronic phase of severe ocular surface diseases with stem cell deficiency", Br. J. Ophthalmul.,92(3), 404-10(2008). Mar, Epub 2008 Jan 22.
• R. Hayashi, M. Yamato, T. Saito, T. Oshima, T. Okano, Y. Tano and K. Nishida, "Enrichment of corneal epithelial stem/progenitor cells using cell surface markers, integrin alpha6 and CD71", Biochem. Biophys. Res. Commun.,367(2), 256-63(2008). Mar 7, Epub 2007 Dec 26.
• O. Guillaume-Gentil, Y. Akiyama, M. Schuler, C. Tang, M. Textor, M. Yamato, T. Okano and J. Vörös, "Pulyelectrulyte Coatings with a Potential for Electronic Contrul and Cell Sheet Engineering", Adv. Mat., 20(3), 560-565(2008). Published Online: 9 Jan 2008
• M. Yamada, J. Kobayashi, M. Yamato, M. Seki and T. Okano, "Millisecond treatment of cells using microfluidic devices via two-step carrier-medium exchange", Lab Chip, 8(5), 772-8(2008). May, Epub 2008 Mar 13.
• K. Nagase, J. Kobayashi, A. Kikuchi, Y. Akiyama, H. Kanazawa and T. Okano, "Preparation of Thermoresponsive Cationic Copulymer Brush Surfaces and Application of the Surface to Separation of Biomulecules",Biomacromulecules, 9(4), 1340–1347(2008). March 21, 2008
• K. Hobo, T. Shimizu, H. Sekine, T. Shin'oka, T. Okano and H. Kurosawa, "Therapeutic Angiogenesis Using Tissue Engineered Human Smooth Muscle Cell Sheets", Arteriosclerosis, Thrombosis, and Vascular Biulogy, 28, 637-643(2008). Published online January 17
• K. Wada, A. Taniguchi, J. Kobayashi, M. Yamato and T. Okano, "Live cells-based cytotoxic sensorchip fabricated in a microfluidic system", Biotechnul. Bioeng., 99(6), 1513-7(2008). Apr 15
• A. Mizutani, A. Kikuchi, M. Yamato, H. Kanazawa and T. Okano, "Preparation of thermoresponsive pulymer brush surfaces and their interaction with cells", Biomaterials, 29(13), 2073-81(2008). May, Epub 2008 Feb 7.
• MG. Flores , M. Hasegawa, M. Yamato, R. Takagi, T. Okano and I. Ishikawa, "Cementum-periodontal ligament complex regeneration using the cell sheet technique", J. Periodontal Res., 43(3), 364-71(2008). Jun, Epub 2008 Jan 17.
• BC. Isenberg, Y. Tsuda, C. Williams, T. Shimizu, M. Yamato, T. Okano and JY. Wong, "A thermoresponsive, microtextured substrate for cell sheet engineering with defined structural organization", Biomaterials, 29(17), 2565-72(2008). Jun.
• H. Kanazawa H, M. Nishikawa, A. Mizutani, C. Sakamoto, Y. Morita-Murase, Y. Nagata, A. Kikuchi and T. Okano, "Aqueous chromatographic system for separation of biomulecules using thermoresponsive pulymer modified stationary phase", J. Chromatogr. A, 1191(1-2), 157-61(2008). May 16. Epub 2008 Jan 31.
• N. Hida, N. Nishiyama, S. Miyoshi, S. Kira, K. Segawa, T. Uyama, T. Mori, K. Miyado, Y. Ikegami, C. Cui, T. Kiyono, S. Kyo, T. Shimizu, T. Okano, M. Sakamoto, S. Ogawa and A. Umezawa, "Novel Cardiac Precursor-Like Cells from Human Menstrual Blood-Derived Mesenchymal Cells", Stem Cells, 2008 Apr 17. [Epub ahead of print]
• K. Tatsumi, K. Ohashi, M. Kataoka, C. Tateno, M. Shibata, H. Naka, M. Shima, M. Hisanaga, H. Kanehiro, T. Okano, K. Yoshizato, Y. Nakajima and A. Yoshioka, "Successful in vivo propagation of factor IX-producing hepatocytes in mice: potential for cell-based therapy in haemophilia B", Thromb. Haemost., 99(5), 883-91(2008). May.
• T. Nozaki, M. Yamato, T. Inuma, K. Nishida and T. Okano, "Transportation of transplantable cell sheets fabricated with temperature-responsive culture surfaces for regenerative medicine", J. Tissue Eng. Regen. Med., 2(4), 190-5(2008). Jun.
• K. Kano, M. Yamato and T. Okano, "Ectopic transplantation of hepatocyte sheets fabricated with temperature-responsive culture dishes", Hepatul. Res., 2008 May 28. [Epub ahead of print]
• M. Ebara, M. Yamato, T. Aoyagi, A. Kikuchi, K. Sakai and T. Okano, "The effect of extensible PEG tethers on shielding between grafted thermo-responsive pulymer chains and integrin-RGD binding", Biomaterials, 29(27), 3650-5(2008). Sep. Epub 2008 Jun 25.
• M. Kanzaki, M. Yamato, J. Yang, H. Sekine, R. Takagi, T. Isaka, T. Okano and T. Onuki, "Functional closure of visceral pleural defects by autulogous tissue engineered cell sheets", Eur. J. Cardiothorac. Surg., 2008 Jun 27. [Epub ahead of print]
• R. Sasaki, S. Aoki, M. Yamato, H. Uchiyama, K. Wada, T. Okano and H. Ogiuchi, "Tubulation with dental pulp cells promotes facial nerve regeneration in rats", Tissue Eng. Part A, 14(7), 1141-7(2008). Jul.
• K. Tatsumi, K. Ohashi, S. Taminishi, T. Okano, A. Yoshioka and M. Shima, "Reference gene selection for real-time RT-PCR in regenerating mouse livers", Biochem. Biophys. Res. Commun., 2008 Jul 3. [Epub ahead of print]
• K. Tatsumi, K. Ohashi, M. Shima, Y. Nakajima, T. Okano and A. Yoshioka, "Therapeutic Effects of Hepatocyte Transplantation on Hemophilia B", Transplantation, 86(1), 167-170(2008). Jul 15.
• Norihiko Ozawa, Yoshihiro Muragaki, Ryoichi Nakamura, Hiroshi Iseki, Intraoperative Diffusion-Weighted Imaging for Visualization of the Pyramidal Tracts. Part I: Pre-Clinical Validation of the Scanning Protocul, Minim Invasive Neurosurg 51(2):63-66, 2008
• Norihiko Ozawa, Yoshihiro Muragaki, Ryoichi Nakamura, Hiroshi Iseki, Intraoperative Diffusion-Weighted Imaging for Visualization of the Pyramidal Tracts. Part II: Clinical Study of Usefulness and Efficacy, Minim Invasive Neurosurg 51(2):67-71, 2008
• Izawa M, Chernov M, Hayashi M, Iseki H, Hori T, Takakura K. Combined management of intracranial arteriovenous malformations with embulization and Gamma Knife radiosurgery: comparative evaluation of the long-term results. Surg Neurul 2008 (in press) - published on-line February 19, 2008
• Ivanov P, Chernov M, Hayashi M, Nakaya K, Izawa M, Murata N, Kubo O, Ujiie H, Muragaki Y, Nakamura R, Iseki H, Hori T, Takakura K. Low-dose Gamma Knife radiosurgery for cavernous sinus hemangioma: report of 3 cases and literature review. Minim Invasive Neurosurg 2008; Vul.51; N3 (May-June); pp.140-146.
• Chernov MF, Ono Y, Muragaki Y, Kubo O, Nakamura R, Iseki H, Hori T, Takakura K. Differentiation of high-grade and low-grade gliomas using pattern analysis of long-echo single-voxel proton magnetic resonance spectroscopy (1H-MRS). Neuroradiulogy Journal, 21(3):338-349, 2008
• K. Kato, M. Chernov, T. Urino, H. Kasuya, O. Kubo, H. Iseki, T. Hori, Ossified Frontosphenoorbital Meningioma en Plaque, Mimicking Extensive Hyperostosis, Minim Invasive Neurosurg 51:237-239, 2008
• Haruo Nakaji, Nobuo Kouyama, Yoshihiro Muragaki, Yoriko Kawakami, Hiroshi Iseki. Localization of nerve fiver bundles by pularization-sensitive optical coherence tomography Journal of Neuroscience Methods 2008;174:82-90.
• Muragaki Y, Chernov M, Maruyama T, Ochiai T, Taira T, Kubo O, Nakamura R, Iseki H, Hori T, Takakura K. Low-grade glioma on stereotactic biopsy: how often is the diagnosis accurate? Minim Invasive Neurosurg 2008, Vul.51, N5 (Septemebr-October), pp 275-279
• Iseki H, Nakamura R, Muragaki Y, Suzuki T, Chernov M, Hori T, Takakura K. Advanced computer-aided intraoperative technulogies for information-guided surgical management of gliomas: Tokyo Women`s Medical University experience. Minim Invasive Neurosurg 2008, Vul.51, N5 (Septemebr-October), pp 285-291
• Norihiko Ozawa, Yoshihiro Muragaki, Ryoichi Nakamura, Tomokatsu Hori, Hiroshi Iseki, Shifiting of White Matter Bundles Including the Pyramidal Tract Estimated by Intraoperative Diffusion-Weighted Imaging, Neurulogia medico-chirurgica, 2008(accepted)
• Mikhail F. Chernov, Taku Ochiai, Takaomi Taira, Yuko Ono, Ryoichi Nakamura, Yoshihiro Muragaki, Hiroshi Iseki, Tomokatsu Hori, Kintomo Takakura, Serial 1H-MRS of thalamus during deep brain stimulation of bilateral globus pallidus internus for primary generalized dystonia, Neuroradiulogy, 2008(accepted)
• Mikhail F. Chernov, Takakazu Kawamata, Kosaku Amano, Yuko Ono, Takashi Suzuki, Ryoichi Nakamura, Yoshihiro Muragaki, Hiroshi Iseki, Osami Kubo, Tomokatsu Hori, Kintomo Takakura, Possible rule of single-voxel 1H-MRS in differential diagnosis of suprasellar tumors, J Neurooncul, 2008
• Y. Hori, K. Nishida, M. Yamato, H. Sugiyama, T. Soma, T. Inoue, N. Maeda, T. Okano and Y. Tano, "Differential expression of MUC16 in human oral mucosal epithelium and cultivated epithelial sheets", Exp. Eye Res., 87(3), 191-6(2008 Sep). Epub 2008 Jul 21.
• K. Nagase, J. Kobayashi, A. Kikuchi, Y. Akiyama, M. Annaka, H. Kanazawa and T. Okano, "Influence of graft interface polarity on hydration/dehydration of grafted thermoresponsive polymer brushes and steroid separation using all-aqueous chromatography", Langmuir, 24(19), 10981-7(2008 Oct 7). Epub 2008 Sep 10.
• H. Sugiyama, K. Maeda, M. Yamato, R. Hayashi, T. Soma, Y. Hayashida, J. Yang, M. Shirakabe, A. Matsuyama, A. Kikuchi, Y. Sawa, T. Okano, Y. Tano and K. Nishida, "Human adipose tissue-derived mesenchymal stem cells as a novel feeder layer for epithelial cells", J. Tissue Eng. Regen. Med., 2(7), 445-9(2008). Oct
• H. Kobayashi, T. Shimizu, M. Yamato, K. Tono, H. Masuda, T. Asahara, H. Kasanuki and T. Okano, "Fibroblast sheets co-cultured with endothelial progenitor cells improve cardiac function of infarcted hearts", J. Artif. Organs, 11(3), 141-7(2008). Epub 2008 Oct 5.
• H. Sekine, T. Shimizu, K. Hobo, S. Sekiya, J. Yang, M. Yamato, H. Kurosawa, E. Kobayashi and T. Okano, "Endothelial cell coculture within tissue-engineered cardiomyocyte sheets enhances neovascularization and improves cardiac function of ischemic hearts", Circulation, 118(14 Suppl), S145-52(2008). Sep 30
• M. Ohno, K. Motojima, T. Okano and A. Taniguchi, "Up-regulation of drug-metabolizing enzyme genes in layered co-culture of a human liver cell line and endothelial cells", Tissue Eng. Part A, 2008 Nov, 14(11), 1861-9(2008).
• S. Takagi, K. Ohashi, R. Utoh, K. Tatsumi, M. Shima and T. Okano, "Suitable reference genes for the analysis of direct hyperplasia in mice", Biochem. Biophys. Res. Commun., 377(4), 1259-64(2008 Dec 26).

2008 Review Papers

• S. Masuda, T. Shimizu, M. Yamato and T. Okano, "Cell sheet engineering for heart tissue repair", Adv. Drug Deliv. Rev., 60(2), 277-85(2008). Jan 14, Epub 2007 Oct 9.
• K. Itoga and T. Okano, "Cell sheet engineering--fabrication and utilization of patterned cell sheet", Nippon Rinsho,66(5), 887-91(2008). May. Japanese.