2019年の研究業績

≫ FATSの研究業績はこちら


原著論文 | 総説等 | 著書 | 新聞 | 雑誌・取材記事 | 受賞

2019 原著論文 / Original Papers →女子医大業績データベース

  1. NIIMI Yosuke†, MATSUMINE Hajime*, TAKEUCHI Yuichi, OSAKI Hironobu, TSUNODA Satoshi, MIYATA Mariko, YAMATO Masayuki, SAKURAI Hiroyuki, “A collagen-coated PGA conduit for interpositional-jump graft with end-to-side neurorrhaphy for treating facial nerve paralysis in rat.”, Microsurgery, 39(1):70-80(2019/01)
  2. Lee Jong-Min†, Kim Hyun-Yi, Park Jin-Sung, Lee Dong-Joon, Zhang Sushan, Green David William, Okano Teruo, Hong Jeong-Ho, Jung Han-Sung*, “Developing palatal bone using human mesenchymal stem cell and stem cells from exfoliated deciduous teeth cell sheets”, Journal of tissue engineering and regenerative medicine, 13(2):319-327(2019/01)
  3. LIU Xiaoling†, XU Qian, LONG Xinyu, LIU Weiwei, ZHAO Yeli, HAYASHI Toshihiko, HATTORI Shunji, FUJISAKI Hitomi, OGURA Takaaki, TASHIRO Shin-Ichi, ONODERA Satoshi, YAMATO Masayuki, IKEJIMA Takashi*, “Silibinin-induced autophagy mediated by PPARα-sirt1-AMPK pathway participated in the regulation of type I collagen-enhanced migration in murine 3T3-L1 preadipocytes.”, Molecular and cellular biochemistry, 450(1-2):1-23(2019/01)
  4. UESUGI Kaoru†, SAKUMA Yui, AKIYAMA Yoshitake, AKIYAMA Yoshikatsu, IWABUCHI Kikuko, OKANO Teruo, MORISHIMA Keisuke*, “Temperature-responsive culture surfaces for insect cell sheets to fabricate a bioactuator”, Advanced robotics : the international journal of the RoboticsSociety of Japan., 33(5):219-231(2019/01)
  5. XU Qian†, LIU Xiaoling, LIU Weiwei, HAYASHI Toshihiko, YAMATO Masayuki, FUJISAKI Hitomi, HATTORI Shunji, TASHIRO Shin-Ichi, ONODERA Satoshi, IKEJIMA Takashi*, “Type I collagen-induced YAP nuclear expression promotes primary cilia growth and contributes to cell migration in confluent mouse embryo fibroblast 3T3-L1 cells.”, Molecular and cellular biochemistry, 450(1-2):87-96(2019/01)
  6. RYU Bikei†, SEKINE Hidekazu, HOMMA Jun, KOBAYASHI Tomonori, KAWAMATA Takakazu, SHIMIZU Tatsuya, “Allogeneic adipose-derived mesenchymal stem cell sheet that produces neurological improvement with angiogenesis and neurogenesis in a rat stroke model.”, Journal of neurosurgery, Epub ahead of print(2019/02)
  7. SATO Masato†*, YAMATO Masayuki, MITANI Genya, TAKAGAKI Tomonori, HAMAHASHI Kosuke, NAKAMURA Yoshihiko, ISHIHARA Miya, MATOBA Ryo, KOBAYASHI Hiroyuki, OKANO Teruo, MOCHIDA Joji, WATANABE Masahiko, “Combined surgery and chondrocyte cell-sheet transplantation improves clinical and structural outcomes in knee osteoarthritis.”, NPJ Regenerative medicine, 4:Article number 4(2019/02)
  8. ISHIDA Masaru†, MIYAGAWA Shigeru, SAITO Atsuhiro, FUKUSHIMA Satsuki, HARADA Akima, ITO Emiko, OHASHI Fumiya, WATANABE Tadashi, HATAZAWA Jun, MATSUURA Katsuhisa, SAWA Yoshiki, “Transplantation of human induced pluripotent stem cell-derived cardiomyocytes is superior to somatic stem cell therapy for restoring cardiac function and oxygen consumption in a porcine model of myocardial infarction.”, Transplantation, 103(2):291-298(2019/02)
  9. OKA Masatoshi†, SEKIYA Sachiko, SAKIYAMA Ryoichi, SHIMIZU Tatsuya*, NITTA Kosaku, “Hepatocyte Growth Factor-Secreting Mesothelial Cell Sheets Suppress Progressive Fibrosis in a Rat Model of CKD.”, Journal of the American Society of Nephrology : JASN, 30(2):261-276(2019/02)
  10. MATSUURA Katsuhisa†*, WADA Masanori, SAKAGUCHI Katsuhisa, MATSUHASHI Yuki, SHIMIZU Tatsuya, “Adequate taylor couette flow-mediated shear stress is useful for dissociating human iPS cell-derived cell aggregates”, Regenerative therapy, Epub ahead of print(2019/04)
  11. ITO Kyoji†, MATSUURA Katsuhisa*, MIHARA Yuichiro, SAKAMOTO Yoshihiro, HASEGAWA Kiyoshi, KOKUDO Norihiro, SHIMIZU Tatsuya, “Delivery of pancreatic digestive enzymes into the gastrointestinal tract by pancreatic exocrine tissue transplant”, Scientific Reports, 9(1):5922(2019/04)
  12. TAKAHARA Shingo†, INOUE Shin-ichi, MIYAGAWA-TOMITA Sachiko, MATSUURA Katsuhisa, NAKASHIMA Yasumi, NIIHORI Tetsuya, MATSUBARA Yoichi, SAIKI Yoshikatsu, AOKI Yoko*, “New Noonan syndrome model mice with RIT1 mutation exhibit cardiac hypertrophy and susceptibility to β-adrenergic stimulation-induced cardiac fibrosis.”, EBioMedicine, 42:43-53(2019/04)
  13. KANZAKI Masato†*, TAKAGI Ryo, YAMATO Masayuki, ISAKA Tamami, “Off-the-Shelf Cell Sheets as a Pleural Substitute for Closing Visceral Pleural Injuries.”, Biopreservation and biobanking, 17(2):163-170(2019/04)
  14. AKIMOTO Jun†, NAKAYAMA Masamichi*, TAKAGI Soichi, OKANO Teruo, “Efficient intrahepatic tumor generation by cell sheet transplantation to fabricate orthotopic hepatocarcinoma-bearing model mice for drug testing”, Journal of Biomedical Materials Research Part A, 107(5):1071-1079(2019/05)
  15. MIYABE Yoei†, SEKIYA Sachiko, SUGIURA Naoko, OKA Masatoshi, KARASAWA Kazunori, MORIYAMA Takahito, NITTA Kosaku, SHIMIZU Tatsuya*, “Renal subcapsular transplantation of hepatocyte growth factor-producing mesothelial cell sheets improves ischemia-reperfusion infury.”, American Journal of Physiology-Renal Physiology, 317(2):F229-F239(2019/05)
  16. EBATA Ryota†*, YASUKAWA Kumi, NAGAI Kazue, SAITO Yuko, HIGASHI Kouji, HOMMA Jun, TAKADA Nobuyuki, TAKECHI Fumie, SAITO Naoki, KOBAYASHI Hironobu, OKUNUSHI Kentaro, HAMADA Hiromichi, KOHNO Yoichi, HANAOKA Hideki, SHIMOJO Naoki, “Sivelestat Sodium Hydrate Treatment for refractory Kawasaki Disease Patients.”, Pediatrics international : official journal of the Japan Pediatric Society, 61(5):438-443(2019/05)
  17. MORINO Tsunetaro†, TAKAGI Ryo, YAMAMOTO Kazuhisa, KOJIMA Hiromi, YAMATO Masayuki*, “Explant culture of oral mucosal epithelial cells for fabricating transplantable epithelial cell sheet.”, Regenerative therapy, 10:36-45(2019/06)
  18. KAIBUCHI Nobuyuki†, IWATA Takanori, ONIZUKA Satoru, YANO Kosei, TSUMANUMA Yuka, YAMATO Masayuki, OKANO Teruo*, ANDO Tomohiro, “Allogeneic multipotent mesenchymal stromal cell sheet transplantation promotes healthy healing of wounds caused by zoledronate and dexamethasone in canine mandibular bones”, Regenerative Therapy, 10:77-83(2019/06)
  19. SEKIYA Sachiko*, KIKUCHI Tetsutaro, SHIMIZUTatsuya, “Perfusion culture maintained with an air-liquid interface to stimulate epithelial cellorganization in renal organoids in vitro”, BMC Biomedical Engineering, 1:Article number 15(2019/07)
  20. AOYAMA Junya†, HOMMA Kohei, TANABE Nari, USUI Sumiko, MIYAGI Yasuo, MATSUURA Katsuhisa, KANEDA Makoto, NITTA Takashi*, “Spatiotemporal imaging documented the maturation of the cardiomyocytes from human induced pluripotent stem cells”, The journal of thoracic and cardiovascular surgery, Epub ahead of print(2019/07)
  21. NAM Kihoon†, KIM Kyungsook, DEAN Spencer M, BROWN Callie T, DAVIS Ryan S, OKANO Teruo, BAKER Olga J*, “Using cell sheets to regenerate mouse submandibular glands.”, NPJ Regenerative medicine, 4:16(2019/07)
  22. GAO Botao†, SAKAGUCHI Katsuhisa, MATSUURA Katsuhisa, OGAWA Tetsyta, KAGAWA Yuki, KUBO Hirogsugu, SHIMIZU Tatsuya*, “In vitro Production of Human Ballooned Hepatocytes in a Cell Sheet-based Three-dimensional Model”, Tissue engineering. Part A., Epub ahead of print(2019/08)
  23. RYU Bike†, SEKINE Hidekazu*, KAWAMATA Takakazu, SHIMIZU Tatsuya, “Sticker method for preparation of frozen section using adhesive film.”, Journal of neuroscience methods, 328:108436(2019/09)
  24. SANO Kazunori†, HOMMA Jun, SEKINE Hidekazu*,KOBAYASHI Eiji, SHIMIZU Tatsuya, “Intermittent application of external positive pressure helps to preserve organ viability during ex vivo perfusion and culture.”, Journal of Artificial Organs, Epub ahead of print(2019/10)
  25. KIM Kyungsook†, BOU-GHANNAM Sophia, THORP Hallie, GRAINGER David W., OKANO Teruo*, “Human mesenchymal stem cell sheets in xeno-free media for possible allogenic applications.”, Scientific Reports, 9:Article number 14415(2019/10)
  26. HARAGUCHI Yuji†, KAGAWA Yuki, KUBO Hirotsugu, SHIMIZU Tatsuya*, “Analysis of force vector field during centrifugation for optimizing cell sheet adhesion.”, Biotechnology progress, 35(5):e2857(2019/10)
  27. TAKEMURA Shunsuke†, SHIMIZU Tatsuya*, OKA Masatoshi, SEKIYA Sachiko, BABAZONO Tstsuya, “Transplantation of adipose‐derived mesenchymal stem cell sheets directly into the kidney suppresses the progression of renal injury in a diabetic nephropathy rat model”, Journal of Diabetes Investigation, Epub ahead of print(2019/10)
  28. IMAFUKU Aya†, OKA Masatoshi, MIYABE Yoei, SEKIYA Sachiko, NITTA Kosaku, SHIMIZU Tatsuya*, “Rat mesenchymal stromal cell sheets suppress renal fibrosis via microvascular protection”, Stem Cells Journals, Epub ahead of print(2019/11)
  29. INUI Akitoshii†, SEKINE Hidekazu*, SANO Kazunori, DOBASHI Izumi, YOSHIDA Azumi, MATSUURA Katsuhisa, ONO Minoru, SHIMIZU Tatsuya, “Generation of a large-scale vascular bed for the in vitro creation of three-dimensional cardiac tissue”, Regenerative therapy, 11:316-323(2019/12)

2019 総説等 / Review Papers →女子医大業績データベース

  1. TAKAHASHI Hironobu†*, OKANO Teruo, “Thermally-triggered fabrication of cell sheets for tissue engineering and regenerative medicine.”, Advanced drug delivery reviews, 138(1):276-292(2019/01)
  2. 村上大輔†, 大木岳志, 高木 亮, 原田英明, 天野祐二, 大和雅之, “(特集 再生医療を学ぶ-Translational researchの再先端-)口腔粘膜上皮細胞シート移植による食道粘膜再生”, "消化器病学サイエンス, 3(1):32-37(2019/03)
  3. KOBAYASHI Jun†, OKANO Teruo*, “Design of temperature-responsive polymer-grafted surfaces for cell sheet preparation and manipulation”, Bulletin of the Chemical Society of Japan, 92(4):817-824(2019/04)
  4. KOBAYASHI Jun†*, KIKUCHI Akihiko, AOYAGI Takao, OKANO Teruo*, “Cell sheet tissue engineering: Cell sheet preparation, harvesting/manipulation, and transplantation”, Journal of Biomedical Materials Research Part A, 107(5):955-967(2019/05)
  5. IWASAKI Kengo†, WASHIO Kaoru, MEINZER Walter, TSUMANUMA Yuka, YANO Kosei, ISHIKAWA Isao*, “Application of cell-sheet engineering for new formation of cementum around dental implants.”, Heliyon, 5(6):e01991(2019/06)
  6. 関根秀一†, “細胞シートの多層化と組織スケールアップ”, "PHARMSTAGE, 19(3):6-9(2019/06)
  7. GAO Botao†, MATSUURA Katsuhisa*, SHIMIZU Tatsuya, “Recent progress in induced pluripotent stem cell-derived cardiac cell sheets for tissue engineering”, BioScience Trends, 13(4):292-298(2019/08)
  8. SASAKI Ryo†*, MATSUMINE Hajime, WATANABE Yorikatsu, ANDO Tomohiro, YAMATO Masayuki, “A cage cleaning method for researchers without a cage-washing machine or cage-washing staff”, Regenerative Therapy, 11:73-74(2019/12)
  9. YAMATO Masayuki, “Re: "The next phase of human gene-therapy oversight"”, Regenerative Therapy, 11:1(2019/12)
  10. KIM Kyungsook†*, GRAINGER David W, OKANO Teruo, “Utah's cell sheet tissue engineering center.”, Regenerative therapy, 11:2-4(2019/12)

2019 著書 / Books →女子医大業績データベース

  1. 高木亮, 大和雅之, "特定細胞加工物 / 再生医療等製品の安全性", テキストブック 再生医療 ~創る、行う、支える~, 日本再生医療学会 監修, 一般社団法人 日本再生医療学会, 1,,188-200(2019/03)
  2. 戸部友輔, 清水達也, "脱細胞化小腸を用いた組織再生研究の現状", 脱細胞化組織の作製法と医療・バイオ応用, 監修:岸田晶夫、山岡哲二、千場隆志, シーエムシー出版, 131-139(2019/04)
  3. 関根秀一, "細胞シート工学を基盤とした立体臓器製造技術", バイオ3Dプリント関連技術の開発と応用場, , シーエムシー出版, 第4章,,182(2019/08)
  4. TAKAHASHI Hironobu, SHIMIZU Tatsuya, OKANO Teruo, "Intelligent Surfaces for Cell Sheet Engineering", Principles of Regenerative Medicine, Anthony Atala, Robert Lanza, Antonios G. Mikos, Robert Nerem, Elsevier, 3,,469-484(2019/08)
  5. YANO Kazuo, YAMATO Masayuki, "Regulatory Approaches and Marketing Approvals: A Comparison of Three Systems", Encyclopedia of Tissue Engineering and Regenerative Medicine, Rui L. Reis, Academic Press, Elsevier, 3,,167-206(2019)
  6. GAO Botao, SHIMIZU Tatsutya, OKANO Teruo, "Cell Sorting, Culture, Preconditioning, and Modulation/Cell Aggregates:Sheets", Vascularization for Tissue Engineering and Regenerative Medicine, Wolfgang Holnthoner, Andrea Banfi, James Kirkpatrick, Heinz Redl, Springer International Publishing, .(2020/05)

2019 新聞 / Newspaper

  1. 2019.1.1 時事ドットコム
    清水達也, “微細で柔軟なセンサーで計測=心筋細胞シートの電位-東大など”
  2. 2019.1.1 日本経済新聞web
    清水達也, “心臓への副作用、iPSで把握 新薬開発に応用”
  3. 2019.1.2 マイナビニュース
    清水達也, “細胞と同等の柔らかさを持つセンサ -心筋細胞の表面電位計測に成功”
  4. 2019.1.2 ニュースイッチ
    清水達也, “心筋細胞の表面電位を超柔軟センサーで測定、拍動を妨げず”
  5. 2019.1.11 科学新聞
    清水達也, “拍動する心筋細胞シートの表面電位 極薄ナノメッシュセンサーで計測”
  6. 2019.9.22 山形新聞
    岡野光夫, “細胞シートに未来 再生医療の挑戦 解説 山形医工学研究会”

2019 受賞 / Awards

  1. 日本機械学会 情報・知能・精密機器部門 IIP 2018, ベストプレゼンテーション表彰, 2019.3.22
     大矢貴史 “薄膜電極を用いた心筋細胞電位測定のためのノイズ低減法の検討”
  2. 23th ISHR 2019 ISHR日本部会, Travel Award, 2019.4.22
     Koichiro Miura “Functional evaluation of human bioengineered cardiac tissue using iPS cells derived from dilated cardiomyopathy patients with lamin variant”
  3. 女子医大学会, 平成30年度女子医大医師会賞, 2019.5.27
     松浦勝久 “Induced Pluripotent Stem Cell Elimination in a Cell Sheet by Methionine-Free and 42℃ Condition for Tumor Prevention”
  4. 日本機械学会 ロボティクス・メカトロニクス講演会2018, 若手優秀講演フェロー賞, 2019.6.6
     大矢貴史 “生体電位計測用薄膜電極の特性評価”
  5. 第48回日本口腔インプラント学会学術大会, デンツプライシロナ賞, 2019.9.20
     貝淵信之 “ビーグル犬を用いた間葉系幹細胞シート移植によるビスフォスフォネート関連顎骨壊死の予防効果の検討”
  6. 画像関連学会連合会 第6回秋季大会, 最優秀ポスター賞, 2019.10.31
     大矢貴史 “高い柔軟性を有するシリコーン薄膜のバイオセンサへの応用研究”