On May 1, 1969, the then Institute for Medical Engineering was inaugurated in a room on the second floor of the Research Department building of TWMU's Heart Institute of Japan. Then in 1976, its name was changed to the Institute of Biomedical Engineering and in April 2001, it was reorganized as the Institute of Advanced Biomedical Engineering and Science.

Its founder and director, Shigeru Miura (then Professor) was pioneering in his early focus on the importance of medical engineering for medical science and healthcare, and the growth potential of the medical equipment industry. He drew up and implemented farsighted plans for the Institute, with features that were unheard of that time in Japanese public universities - research and development in medical engineering, especially intra- and extramural joint and contract research, with relevant education and training for medical students and staff.
Yasuhisa Sakurai, Director until March 1999, strongly promoted cooperation between medical science and engineering with the aim of developing the Institute as a progressive and original medical center from a global viewpoint. The understanding and support of the university administration, especially the then Director, Hiroto Yoshioka and Shigeru Sakakibara, Director of the Heart Institute of Japan (both deceased) was a great source of strength.
In April 1999, Professor Teruo Okano became the third Director, and in April 2001, the Advanced Biomedical Science graduate school course began, accepting graduates with Master's degrees in science, engineering and pharmacology.

Then from April 2008, the Institute moved to the Tokyo Women's Medical University - Waseda University Joint Institution for Advanced Biomedical Sciences (TWIns), the new center for biomedical science research combining medicine, science, and engineering, adjacent to the Tokyo Women's Medical University Hospital. Formerly, the Institute's faculty offices were dispersed between the main building and former Tomoe Dormitory, but with the concentration of our facilities in TWIns, we are positioned to pursue advanced medical research, from basic science to clinical applications, at a powerful new level.